体外受精反复失败妇女的诊断评价

作     者：Vaquero E. Lazzarin N. Caserta D. 朱磊 

作者机构：Department of Obstetrics and Gynecology Ospedale Fatebenefratelli University of Rome TorVergata Isola Tiberina 00168 Rome Italy 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第8期

页      码：29-29页

摘      要：Objective: The aim of the study was to propose a set of tests to clarify the diagnosis of repeated implantation failure in patients undergoing in vitro fertilization (IVF). Study design: Fifty-nine patients with at least two unsuccessful IVF attempts were included in the study. Blood samples were evaluated for the presence of underlying thyroid abnormalities, antiphospholipid antibodies (aPL), increased levels of natural killer cells (NK), inherited thrombophilia and mouse embryo assay factor (MEAf). The same tests were performed on 20 normal fertile control patients. Results: Seventy-six percent of IVF patients showed at least one abnormal result. This incidence was higher with respect to that found among control patients (45% ). The prevalence of thyroid abnormalities, aPL and increased NK level was higher in IVF patients whereas no differences were observed in terms of prevalence of inherited thrombophilias and MEAf. Conclusions: A better understanding of reproductive failure mechanisms should allow an effective diagnostic flow chart and a focused therapeutic option for patients experiencing repeated IVF failure. With this objective in mind, our data provide two important results: thyroid abnormalities, aPL and increased NK levels are more prevalent in women experiencing IVF failure. No evidence was found for an association between inherited thrombophilia and MEAf and failure to achieve pregnancy after IVF.

主 题 词：体外受精 诊断评价 抗磷脂抗体 自然杀伤细胞 血液检查 鼠胚 正常生育 诊断流程 系列试验 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

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