Next-generation surgicalmeshes for drug delivery and tissue engineering applications:materials,design and emerging manufacturing technologies

作     者：Francesca Corduas Dimitrios A.Lamprou Elena Mancuso Francesca Corduas;Dimitrios A.Lamprou;Elena Mancuso

作者机构：Nanotechnology and Integrated Bio-Engineering Centre(NIBEC)Ulster UniversityJordanstown CampusNewtownabbey BT370QBUK School of PharmacyQueen’s University BelfastBelfast BT97BLUK 

基　　金：Ulster University  UU 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第2期

页      码：278-310页

摘      要：Surgical meshes have been employed in the management of a variety of pathological conditions including hernia,pelvic floor dysfunctions,periodontal guided bone regeneration,wound healing and more recently for breast plastic surgery after *** common pathologies affect a wide portion of the worldwide population;therefore,an effective and enhanced treatment is crucial to ameliorate patients’living conditions both from medical and aesthetic points of *** present,non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia,pelvic floor dysfunctions and guided bone regeneration,with polypropylene and poly tetrafluoroethylene being the most *** prostheses,such as surgical grafts,have been employed mainly for breast plastic surgery and wound healing *** the advantages of mesh implants to the treatment of these conditions,there are still many drawbacks,mainly related to the arising of a huge number of post-operative complications,among which infections are the most *** a mesh that could appropriately integrate with the native tissue,promote its healing and constructive remodelling,is the key aim of ongoing research in the area of surgical mesh *** this end,the adoption of new biomaterials including absorbable and natural polymers,the use of drugs and advanced manufacturing technologies,such as 3D printing and electrospinning,are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical *** aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes,the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations.

主 题 词：3D printing Electrospinning Manufacturing technologies Biomaterials Drug delivery Surgical mesh implants 

学科分类：08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 

核心收录：

D　O　I：10.1007/s42242-020-00108-1

馆 藏 号：203101692...