Reduced graphene oxide-grafted bovine serum albumin/bredigite nanocomposites with high mechanical properties and excellent osteogenic bioactivity for bone tissue engineering

作     者：Esfandyar Askari Mohammad Rasouli Seyedeh F.Darghiasi Seyed M.Naghib Yasser Zare Kyong Y.Rhee Esfandyar Askari;Mohammad Rasouli;Seyedeh F.Darghiasi;Seyed M.Naghib;Yasser Zare;Kyong Y.Rhee

作者机构：Nanotechnology DepartmentSchool of Advanced TechnologiesIran University of Science and Technology(IUST)P.O.Box 16846-13114TehranIran Biomaterials and Tissue Engineering Research GroupDepartment of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteACECRTehranIran Department of Mechanical EngineeringCollege of EngineeringKyung Hee UniversityYongin 446-701Republic of Korea 

基　　金：Thiswork is financially supported by IranUniversity of Science and Technology(IUST)and Motamed Cancer Institute(ACECR) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第2期

页      码：243-257页

摘      要：The optimization of the scaffolds to provide a suitable matrix and accelerate the regeneration process is vital for bone tissue ***,poor mechanical and biological characteristics remain the primary challenges that must be *** example,although bredigite(Br)has shown great potential for application in bone tissue engineering,it easily fails in *** the present work,these challenges are addressed by reinforcing the Br matrix with nanosheets of graphene oxide(rGO)that have been reduced by bovine serum albumin(BSA)in order to enhance the mechanical properties and biological *** reduction of graphene oxide by BSA improves the water stability of the nanosheets and provides an electrostatic interaction between theBSA-rGO nanosheets and theBr *** high thermal conductivity of theBSA-rGO nanosheets decreases the porosity of the Br by transferring heat to the core of the ***,the addition of BSA-rGO nanosheets into the Br matrix enhances the adhesion of G-292 cells on the surface of the *** findings suggest that the tablet consisting of BSA-rGO-reinforced Br has encouraging potential for application in bone tissue engineering.

主 题 词：Bovine serum albumin(BSA) Reduced graphene oxide(rGO) Bredigite Mechanical properties Bone tissue engineering 

学科分类：08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 

核心收录：

D　O　I：10.1007/s42242-020-00113-4

馆 藏 号：203101694...