Recent advances in chemically defined and tunable hydrogel platforms for organoid culture

作     者：Tarun Agarwal Nehar Celikkin Marco Costantini Tapas K.Maiti Pooyan Makvandi Tarun Agarwal;Nehar Celikkin;Marco Costantini;Tapas K.Maiti;Pooyan Makvandi

作者机构：Department of BiotechnologyIndian Institute of Technology KharagpurKharagpurWest Bengal 721302India Institute of Physical Chemistry-Polish Academy of SciencesWarsawPoland Centre for Micro-BioRoboticsIstituto Italiano di TecnologiaViale Rinaldo Piaggio 3456025 PontederaPisaItaly 

基　　金：Indian Institute of Technology Kharagpur 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第3期

页      码：641-674页

摘      要：Recent developments in organoid culture technologies have made it possible to closely recapitulate intrinsic characteristics of different tissues under in vitro *** organoids act as a translational bridge between the traditional 2D/3D cultures and the in vivo models for studying the tissue development processes,disease modeling,and drug *** and tissue-specific extracellular matrix have been shown to support organoid development,efficiently;however,their chemically undefined nature,non-tunable properties,and associated batch-to-batch variations often limit reproducibility of the assembly *** this regard,chemically defined platforms offer wider opportunities to optimize and recreate tissue-specific *** present review delineates the current research trends in this sphere,focusing on material perspective and the target tissues(e.g.,neural,liver,pancreatic,renal,and intestinal).The review winds up with a discussion on the current limitations and future perspective to provide a basis for future research.

主 题 词：Organoid 3D culture Biomaterials Chemically defined hydrogels Cell-instructive microenvironment 

学科分类：081702[081702] 08[工学] 0817[工学-轻工类] 080501[080501] 0805[工学-能源动力学] 080502[080502] 

核心收录：

D　O　I：10.1007/s42242-021-00126-7

馆 藏 号：203102133...