Transanal vs laparoscopic total mesorectal excision for rectal cancer:a multicenter randomized phase III clinical trial(TaLaR trial)protocol

作     者：Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang 

作者机构：Department of Colorectal SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Institute of GastroenterologyThe Sixth Affiliated Hospital of Sun Yatsen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Colorectal SurgeryShengjing Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Gastrointestinal SurgeryThe First Hospital of Jilin UniversityChangchunJilinP.R.China Department of Gastrointestinal SurgeryThe Affiliated Nanchong Central Hospital of North Sichuan Medical CollegeNanchongSichuanP.R.China Department of Gastrointestinal SurgeryThe Second People’s Hospital of YibinYibinSichuanP.R.China Department of General SurgeryDaping HospitalArmy Medical universityChongqingP.R.China Department of Gastrointestinal SurgeryRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiP.R.China Department of General SurgeryPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingP.R.China Department of Gastrointestinal SurgeryPeking University Cancer HospitalBeijingP.R.China Department of Gastrointestinal SurgeryThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongP.R.China Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Gastrointestinal SurgeryPeking University People’s HospitalBeijingP.R.China 

基　　金：supported by a grant from Fundamental Research Funds for the Central Universities[Grant No.16ykjc25 addressed to L.K.] the Sun Yat-sen University Clinical Research 5010 Program[Grant No.2016005 addressed to L.K.] 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2021年第9卷第1期

页      码：71-76,I0002页

摘      要：Background:Total mesorectum excision(TME)is considered the standard surgical procedure for rectal-cancer *** TME(taTME)is a new procedure to treat low rectal *** published studies have proven that taTME can provide a better-quality resected specimen in low-rectal-cancer patients in comparison to the transabdominal procedure,yet long-term outcomes must be *** designed this non-inferiority trial(TaLaR trial)to compare short-term and long-term outcomes between taTME and laparoscopic TME(lapTME)for rectal ***:The TaLaR trial is a phase III open-labeled multicenter randomized-controlled *** who are diagnosed with rectal cancer with no more than T3N2 stage,and with the tumor location below the peritoneal reflection by magnetic resonance imaging scan,digital rectal examination,or colonoscopy,qualify for this *** calculating,a total of 1,114 patients(557 per group)will be randomly allocated to either the taTME or the lapTME *** endpoints are the 3-year disease-free survival(DFS)rate and the 5-year overall survival(OS)*** endpoints include specimen quality,perioperative results,pelvic and anal function,and quality of ***:The TaLaR trial is expected to clarify whether taTME can achieve comparable oncological outcomes,as well as improve specimen quality and recovery conditions in rectal-cancer patients compared with lapTME.

主 题 词：transanal total mesorectal excision total mesorectal excision laparoscopic rectal cancer surgery 

学科分类：1002[医学-临床医学类] 100214[100214] 10[医学] 

核心收录：

D　O　I：10.1093/gastro/goaa083

馆 藏 号：203102551...