Design synthesis and biological evaluation of 3-substituted triazole derivatives

作     者：Bao Gang Wang Shi Chong Yu Xiao Yun Chai Yong Zheng Yan Hong Gang Hu Qiu Ye Wu 

作者机构：Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Pharmacy Team Administrative Brigade of Postgraduate Second Military Medical University Shanghai 200433 China 

基　　金：supported by the National Natural Science Foundation of China(No.20772153) Shanghai Leading Academic Discipline Project(No.B906) Creativity and Innovation Training Program of Second Military Medical University(No.MS2009042) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2011年第22卷第5期

页      码：519-522页

摘      要：Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal *** of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

主 题 词：Synthesis Triazole Antifungal activity 1 3-Dipolar cycloaddition 

学科分类：1007[医学-药学类] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 10[医学] 

核心收录：

D　O　I：10.1016/j.cclet.2010.11.029

馆 藏 号：203102621...