A bifunctional bone scaffold combines osteogenesis and antibacterial activity via in situ grown hydroxyapatite and silver nanoparticles

作     者：Youwen Yang Yun Cheng Fang Deng Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai Youwen Yang;Yun Cheng;Fang Deng;Lida Shen;Zhenyu Zhao;Shuping Peng;Cijun Shuai

作者机构：Institute of Bioadditive ManufacturingJiangxi University of Science and TechnologyNanchang 330013China Jiangsu Key Laboratory of Precision and Micro-Manufacturing TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China Shenzhen Institute of Information TechnologyShenzhen 518172China NHC Key Laboratory of CarcinogenesisSchool of Basic Medical ScienceCentral South UniversityChangsha 410013China School of Energy and Machinery EngineeringJiangxi University of Science and TechnologyNanchang 330013China State Key Laboratory of High Performance Complex ManufacturingCentral South UniversityChangsha 410083China 

基　　金：This study was supported by the following funds:(1)National Natural Science Foundation of China(Nos.51935014,82072084,and 81871498) 2)Jiangxi Provincial Natural Science Foundation of China(Nos.20192ACB20005 and 2020ACB214004 3)The Provincial Key R&D Projects of Jiangxi(No.20201BBE51012 4)Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme(2018 5)Shenzhen Science and Technology Plan Project(No.JCYJ20170817112445033 6)Innovation Team Project on University of Guangdong Province(No.2018GKCXTD001 7)Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020(No.PT2020E002 (8)Open Research Fund of Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology 9)China Postdoctoral Science Foundation(No.2020M682114 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第3期

页      码：452-468页

摘      要：Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer ***,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these *** this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline ***,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering *** showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical *** body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent *** vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia ***,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.

主 题 词：Bone scaffold In situ growth Hydroxyapatite Antibacterial properties Surface modification 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 0817[工学-轻工类] 08[工学] 0807[工学-电子信息类] 080501[080501] 0805[工学-能源动力学] 080502[080502] 0802[工学-机械学] 0836[0836] 0811[工学-水利类] 

核心收录：

D　O　I：10.1007/s42242-021-00130-x

馆 藏 号：203103046...