Screening the Optimal Patterned Surfaces Consisting of Cell Morphology Mimicking Micro-pillars and Nanotube Arrays for the Design of Titanium Implants#br#

作     者：Ping Zhou Hongjiao Li Feifei Mao Hongxin Huang Siqi Long Fei He Jing Chen Shicheng Wei Ping Zhou;Hongjiao Li;Feifei Mao;Hongxin Huang;Siqi Long;Fei He;Jing Chen;Shicheng Wei

作者机构：School and Hospital of StomatologyLanzhou UniversityLanzhou 730000China Central LaboratoryPeking University School and Hospital of StomatologyBeijing 100081China Institute of MicroelectronicsPeking UniversityBeijing 100871China 

基　　金：This work was funded by the National Natural Science Foundation of China(No.81801855) Young Elite Scientist Sponsorship Program by CSA(No.2018QNRC001) Fundamental Research Funds for the Central Universities,Chengguan District Science and Technology Project(No.2018-7-6) Lanzhou University Hospital of Stomatology Research Support Fund 

出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)

年 卷 期：2021年第18卷第2期

页      码：361-374页

摘      要：Micron/nano scale topographic modification has been a significant focus of interest in current titanium(Ti)surface ***,the influence of micron/nano structured surface on cell or bacterium behavior on the Ti implant has rarely been systematically ***,except for popular microgrooves,little work has been carried out on the reaction of cells to the bionic *** this study,several micro-pillars mimicking cell morphology were prepared on Ti surfaces by lithography and contact printing(ICP)method,and they were further decorated with nanotube arrays by anodization *** surface modifications remarkablly increased the surface roughness of pristine Ti surface from 91.17 nm±5.57 nm to be more than 1000 nm,and reduced their water contact angles from 68.3°±0.7°to be 16.9°±2.4°.Then,the effects of these hierarchical micron/nano scale patterns on the behaviors of MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and *** were studied,aiming to evaluate their performance in osseointegration,gingival epithelial sealing and antibacterial *** an innovative scoring strategy,our findings showed that square micro-pillars with 6μm width and 2μm height combined with 85 nm diameter nanotubes was suitable for implant neck design,while square micro-pillars with 3μm width and 3.6μm height combined with 55 nm diameter nanotubes was the best for implant body *** study reveals the synergistic effect of the hierarchical micron/nano scale patterns on MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and *** *** provides insight into the design of biomedical implant surfaces.

主 题 词：hierarchical micron/nano design cell-like patterns nanotube arrays titanium implants implant osseointegration 

学科分类：07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 0702[理学-物理学类] 

核心收录：

D　O　I：10.1007/s42235-021-0019-x

馆 藏 号：203103050...