Application of lung microphysiological systems to COVID-19 modeling and drug discovery:a review

作     者：Argus M.Sun Tyler Hoffman Bao Q.Luu Nureddin Ashammakhi Song Li Argus M.Sun;Tyler Hoffman;Bao Q.Luu;Nureddin Ashammakhi;Song Li

作者机构：Department of BioengineeringSamueli School of EngineeringUniversity of California-Los Angeles420 Westwood Plaza 5121 Engineering V University of CaliforniaLos AngelesCA 90095-1600USA UC San Diego HealthcareUCSDLa JollaCA 92037USA Pulmonary Diseases and Critical CareScripps Green HospitalScripps HealthLa JollaCA 92037USA Department of Biomedical EngineeringCollege of EngineeringMichigan State UniversityEast LansingMI 48824USA Department of MedicineDavid Geffen School of MedicineUCLALos AngelesCA 90095USA 

基　　金：funding from National Institutes of Health(No.1UG3TR003148-01) the American Heart Association(No.442611-NU-80922) California Institute for Regenerative Medicine(No.DISC2COVID19-11838) COVID-19 research funding from David Geffen School of Medicine at UCLA 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第4期

页      码：757-775页

摘      要：There is a pressing need for effective therapeutics for coronavirus disease 2019(COVID-19),the respiratory disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** process of drug development is a costly and meticulously paced process,where progress is often hindered by the failure of initially promising *** aid this chal-lenge,in vitro human microphysiological systems need to be refined and adapted for mechanistic studies and drug screening,thereby saving valuable time and resources during a pandemic *** SARS-CoV-2 virus attacks the lung,an organ where the unique three-dimensional(3D)structure of its functional units is critical for proper respiratory *** in vitro lung models essentially recapitulate the distinct tissue structure and the dynamic mechanical and biological interactions between different cell *** model systems include Transwell,organoid and organ-on-a-chip or microphysiological systems(MPSs).We review models that have direct relevance toward modeling the pathology of COVID-19,including the processes of inflammation,edema,coagulation,as well as lung immune *** also consider the practical issues that may influence the design and fabrication of *** role of lung MPS is addressed in the context of multi-organ models,and it is discussed how high-throughput screening and artificial intelligence can be integrated with lung MPS to accelerate drug development for COVID-19 and other infectious diseases.

主 题 词：Bioengineering Microfluidics COVID-19 Organ-on-a-chip Lung Microvascular networks Drug development 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 1002[医学-临床医学类] 0817[工学-轻工类] 0807[工学-电子信息类] 100201[100201] 0805[工学-能源动力学] 0802[工学-机械学] 0836[0836] 0811[工学-水利类] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-021-00136-5

馆 藏 号：203103649...