Introducing 3D-potting:a novel production process for artificial membrane lungs with superior blood flow design

作     者：Fellx Hesselmann Jannls M.Focke Peter C.Schlansteln NIklas B.Steuer Andreas Kaesler Sebastlan D.Relnartz Thomas Schmltz-Rode Ulrlch SteInselfer Sebastlan V.Jansen Jutta Arens Felix Hesselmann;Jannis M.Focke;Peter C.Schlanstein;Niklas B.Steuer;Andreas Kaesler;Sebastian D.Reinartz;Thomas Schmitz-Rode;Ulrich Steinseifer;Sebastian V.Jansen;Jutta Arens

作者机构：Department of Cardiovascular EngineeringInstituteof Applied Medical EngineeringHelmholtz.InstituteRWTH Aachen UniversityPauwelsstrasse 2052074 AachenGermany Department of Diagnostic and Interventional RadiologyUniklinik RWTH AachenPauwelsstrasse 3052074 AachenGermany Department of Biomechanical EngineeringFaculty of EngineeringTechnology University of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands 

基　　金：RWTH Aachen University 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第1期

页      码：141-152页

摘      要：Currently,artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers,achieving diffusive gas *** both ends of the fibers,the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood *** a uniaxial centrifugation process,the glue forms the“potting.”The shape of the cured potting is then determined by the centrifugation process,limiting design possibilities and leading to unfavorable stagnation zones associated with blood *** this study,a new multiaxial centrifugation process was developed,expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting ***-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets.A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs,resulting in good agreement with the *** summary,this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes,eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.

主 题 词：Potting process Flow design Membrane lung Artificial lung Hollow fiber membrane module Manufacturing 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 1004[医学-公共卫生预防医学类] 1002[医学-临床医学类] 08[工学] 0805[工学-能源动力学] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-021-00139-2

馆 藏 号：203103745...