Design and Synthesis of Potential Macrocyclic Zinc Metalloprotease Inhibitors

作     者：赵宝祥 SCHAUDT,Marco BLECHERT,Siegfried 

作者机构：Institute of Organic Chemistry School of Chemistry and Chemical Engineering Shandong University Jinan Shandong 250100 China Institutfiir Chemie Technische Universitat Berlin Strasse des 17. Juni 135 D-10623 Berlin Germany 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2006年第24卷第8期

页      码：1080-1085页

摘      要：A series of succinate-derived macrocyclic amides 1 were synthezized using ring-closing metathesis in the key step. The substrate scope includes rings of 11 to 14 members. The cyclic dicarboxylic acids 1 represent a family of new model compounds for potential zinc metalloprotease inhibitors. The metathesis precursors were provided by amide coupling of tert-butyl 3-carboxyhex-5-enoate 2 with numerous side chain alkenylated amino acid esters of general type 3 derived from L-tyrosine and L-cysteine.

主 题 词：metathesis macrocycle aminoacid derivative 

学科分类：0710[理学-生物科学类] 071010[071010] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 

核心收录：

D　O　I：10.1002/cjoc.200690202

馆 藏 号：203103974...