Bioreactor design and validation for manufacturing strategies in tissue engineering

作     者：Diana Lim Eric S.Renteria Drake S.Sime Young Min Ju Ji Hyun Kim Tracy Criswell Thomas D.Shupe Anthony Atala Frank C.Marini Metin N.Gurcan Shay Soker Joshua Hunsberger James J.Yoo Diana Lim;Eric S.Renteria;Drake S.Sime;Young Min Ju;Ji Hyun Kim;Tracy Criswell;Thomas D.Shupe;Anthony Atala;Frank C.Marini;Metin N.Gurcan;Shay Soker;Joshua Hunsberger;James J.Yoo

作者机构：Wake Forest Institute for Regenerative MedicineWake Forest School of MedicineWinston-SalemNC 27157USA Center for Biomedical InformaticsWake Forest School of MedicineWinston-SalemNC 27157USA RegenMed Development Organization(ReMDO)Winston SalemNC 27106USA 

基　　金：US Army Medical Research and Development Command through the Medical Technology Enterprise Consortium under Contract#W81XWH-15-9-0001 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第1期

页      码：43-63页

摘      要：The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or *** maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for ***,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in ***-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management *** present review provides a brief overview of bioreactor engineering *** addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed.

主 题 词：Bioreactor Monitoring sensors and automation Manufacturing Tissue engineering Regenerative medicine 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 0817[工学-轻工类] 08[工学] 0807[工学-电子信息类] 0805[工学-能源动力学] 0802[工学-机械学] 0836[0836] 0811[工学-水利类] 

核心收录：

D　O　I：10.1007/s42242-021-00154-3

馆 藏 号：203104290...