Recent advances in the development of in vitro liver models for hepatotoxicity testing

作     者：Siming Lu Jingwei Zhang Sha Lin Danfeng Zheng Yan Shen Jiale Qin Yangyang Li Shuqi Wang Siming Lu;Jingwei Zhang;Sha Lin;Danfeng Zheng;Yan Shen;Jiale Qin;Yangyang Li;Shuqi Wang

作者机构：Department of Laboratory MedicineThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalNational Clinical Research Center for Infectious DiseasesZhejiang University School of MedicineHangzhou 310003China Institute of Translational MedicineZhejiang UniversityHangzhou 310029China Key Laboratory of Women’s Reproductive Health of Zhejiang ProvinceWomen’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310027China 

基　　金：supports from General Program from the National Natural Science Foundation of China(No.31871016) the National Key Research and Development Program(2016YFC1101302)from the Ministry of Science and Technology of China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第4期

页      码：717-734页

摘      要：Liver injury is a common cause of drug approval withdrawal during drug development,pre-clinical research,and clinical *** not properly treated,patients with severe liver injury can suffer from acute liver failure or even ***,utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized ***(e.g.,hydrogels,nanofibers,decellularized liver matrix)and bioengineering technologies(e.g.,microarrays,micropatterns,3D printing,and microfluidics)have been applied for in vitro hepatotoxicity assessment *** review summarizes the structure and functions of the liver as well as the components of in vitro hepatotoxicity assessment *** addition,it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation.

主 题 词：Liver injury Drug toxicity In vitro model 3D culture 

学科分类：1002[医学-临床医学类] 100201[100201] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-021-00142-7

馆 藏 号：203104597...