Electrospinning of a sandwich-structured membrane with sustained release capability and long-term anti-inflammatory effects for dental pulp regeneration

作     者：Fenghe Yang Jiangxue Wang Xiaoyu Li Zhenzhen Jia Qiang Wang Dazhi Yu Jinyu Li Xufeng Niu Fenghe Yang;Jiangxue Wang;Xiaoyu Li;Zhenzhen Jia;Qiang Wang;Dazhi Yu;Jinyu Li;Xufeng Niu

作者机构：Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Burn Plastic Surgery80th Army Hospital of PLAWeifang 261021China Department of Hand Surgery971st Army Hospital of PLAQingdao 266000China Department of OrthopaedicsDongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China 

基　　金：financial support from the National Natural Science Foundation of China(Nos.11872097,82074463,11827803,and U20A20390) the National Key R&D Program of China(No.2020YFC0122204) the 111 Project(No.B13003) the International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第2期

页      码：305-317页

摘      要：Current electro spun membranes used for pulp capping still lack the sustained-release capability and long-term anti-inflammatory effects that are favorable for dental pulp *** this work,a single-layered poly(lac tic acid)(PLA)electro spun membrane loaded with amorphous calcium phosphate(ACP)and aspirin(PLA/ACP/Aspirin membrane,i.e.,PA A membrane)is sandwiched between two poly(lactic-co-glycolic acid)(PLGA)electro spun membranes as a novel sandwich-structured PLGA and PA A composite electro spun membrane(PLGA-PAA membrane)to resolve the need for sustained-release design and anti-inflammatory *** angle measurements indicate that the PLGA-PAA membrane is more hydrophilic than the PAA *** in vitro release study reveals that PLGA membranes coated on PAA membrane could slightly slow down ion release,while signiificantly prolonging aspirin *** also co-cultured membranes with dental pulp stem cells(DPSCs)and human monocytic THP-1 cells to evaluate their osteogenic ability and anti-inflammatory effects,*** with the PAA membrane,the PLGA-PAA membrane promotes cell adhesion,proliferation,and osteogenic differentiation.A prolonged anti-inflammatory effect of up to 18 days is also observed in the PLGA-PAA *** results suggest a promising strategy for fabricating an electro spun membrane system with controlled release capabilities and long-term anti-inflammatory effects for use as pulp-capping material for regeneration of the dentin-pulp complex.

主 题 词：Electrospinning Sandwich-structured Pulp capping Controlled release Anti-inflammatory effects 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 0817[工学-轻工类] 08[工学] 0807[工学-电子信息类] 0805[工学-能源动力学] 080502[080502] 0802[工学-机械学] 0836[0836] 0811[工学-水利类] 

核心收录：

D　O　I：10.1007/s42242-021-00152-5

馆 藏 号：203104863...