Anisotanols A—D,Four Norsesquiterpenoids with an Unprece-dented Sesquiterpenoid Skeleton from Anisodus tanguticus

作     者：Hao-Yu Zhao Qin-Mei Zhou Huan Zhu Fei Zhou Chun-Wang Meng Hong-Zhen Shu Zhao-Hua Liu Cheng Peng Liang Xiong Hao-Yu Zhao;Qin-Mei Zhou;Huan Zhu;Fei Zhou;Chun-Wang Meng;Hong-Zhen Shu;Zhao-Hua Liu;Cheng Peng;Liang Xiong

作者机构：School of PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan 611137China State Key Laboratory of Southwestern Chinese Medicine ResourcesChengdu University of Traditional Chinese MedicineChengduSichuan 611137China Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal MaterialsChengdu University of Traditional Chinese MedicineChengduSichuan 611137China Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan 611137China Chengdu No.l Pharmaceutical Co.Ltd.ChengduSichuan 610031China 

基　　金：This work was supported by the National Natural Science Foundation of China(NNSFC,Grant Nos.82022072 and 81891012) the Fok Ying Tung Education Foundation(Grant No.171037) the Sichuan Science and Technology Program(Grant No.2018JZ0081) the"Xinglin Scholar"Plan of Chengdu University of TCM(Grant Nos.YXRC2018005,BSH2018009,and QNXZ2019030) 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第12期

页      码：3375-3380页

摘      要：Anisotanols A—D(1-4),four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system,were obtained from Anisodus *** structures were elucidated by comprehensive spectroscopic techniques,and the absolute configurations were confirmed via ECD calculations and single-crystal X-ray diffractions.A putative biosynthetic pathway for these compounds was *** evaluation disclosed that compound 3 showed anti-angiogenic activity by inhibiting the viability,migration,and tube formation in HUVECs.

主 题 词：Anisodus tanguticus Terpenoids Structure elucidation Anisotane-type Angiogenesis 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 

核心收录：

D　O　I：10.1002/cjoc.202100524

馆 藏 号：203106274...