Chemical constituents isolated from the aerial parts of Swertia pseudochinensis and their potential neuroprotective effects

作     者：Ke Xiang Qi He Yanmei Chen Dongxin Yang Yanwei Duan Hua Li Lixia Chen 项珂;何琪;陈彦梅;杨栋鑫;段衍伟;李华;陈丽霞

作者机构：Wuya College of InnovationKey Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyangChina Hubei Key Laboratory of Natural Medicinal Chemistry and Resource EvaluationSchool of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina 

基　　金：financially supported by the Liaoning Revitalization Talents Program(No.XLYC1807182) the Liaoning Province Natural Science Foundation(No.2019-MS-299) 

出 版 物：《Acupuncture and Herbal Medicine》 (针灸和草药（英文）)

年 卷 期：2021年第1卷第1期

页      码：59-64页

摘      要：Objective:Swertia pseudochinensis,an annual herb of the genus Swertia in the family *** constituents and extracts from the Swertia genus have been recently reported to possess neuroprotective effects,suggesting their potential utility in the prevention and treatment of Parkinson disease(PD).The aim of this work is to identify the chemical constituents and evaluate the potential biological activists of Swertia ***:The phytochemicals from the aerial parts of *** were isolated and purified by silica gel,Sephadex LH-20 gel,semi-preparative high-performance liquid chromatography,and identified by the spectroscopic *** compounds were evaluated for their potential neuroprotective effects against 1-methyl-4-phenylpyridinium-induced apoptosis in the SH-SY5Y human neuroblastoma cell line using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide ***,we performed an enrichment analysis using the Database for Annotation,Visualization,and Integrated Discovery and investigated the mechanisms by which bellidifolin regulates neurodegenerative ***:Two new anthraquinone,1,5,6-trimethoxy-2-hydroxy-3-methy-anthraquinone(1)and 1,5,6,8-tetramethoxy-2-hydroxy-3-methyanthraquinone(2),together with nine known including 7-O-b-d-glucopyranosyl-1,8-dihydroxy-3-methoxyxanthone(3),gentisin(4),swertianolin(5),bellidifolin(6),gentiacaulein(7),norswertianolin(8),5-O-b-d-glucopyranosyl-1,3,8-trihydroxyapatone(9),1-hydroxy-3,5,8-trimethoxyxanthone(10),and aurantio-obtusin(11),were isolated and compounds 6–8 and 10 exhibited neuroprotective effects at a concentration of 50mmol/*** them,bellidifolin showed significant protective activity,and might have potential as a neuroprotective agent for the treatment of PD,possibly by acting on oxidative damage and reactive oxygen ***:These findings indicate that further research on the genus Swertia and its bioactive constituents toward neurodegenerative d

主 题 词：Anthraquinone Neuroprotective effect Parkinson disease Swertia pseudochinensis Xanthone 

学科分类：1008[医学-中药学类] 1006[医学-中西医结合类] 100602[100602] 10[医学] 

D　O　I：10.1097/HM9.0000000000000010

馆 藏 号：203106426...