Multiscale design and biomechanical evaluation of porous spinal fusion cage to realize specified mechanical properties

作     者：Hongwei Wang Yi Wan Quhao Li Xinyu Liu Mingzhi Yu Xiao Zhang Yan Xia Qidong Sun Zhanqiang Liu Hongwei Wang;Yi Wan;Quhao Li;Xinyu Liu;Mingzhi Yu;Xiao Zhang;Yan Xia;Qidong Sun;Zhanqiang Liu

作者机构：Key Laboratory of High Efficiency and Clean ManufacturingSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China Department of OrthopedicsQilu Hospital of Shandong UniversityJinan 250012China 

基　　金：financially supported by the National Natural Science Foundation of China(No.51975336) the Key Basic Research Project of Natural Science Foundation of Shandong Province,China(No.ZR2018ZB0106) the Key Research and Development Program of Shandong Province,China(No.2019JZZY010112) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第2期

页      码：277-293页

摘      要：Backgrou nd Dense titanium(Ti)fusion cages have been commonly used in transforaminal lumbar interbody ***,the stiffness mismatch between cages and adjacent bone endplates increases the risk of stress shielding and cage *** The current study presents a multiscale optimization approach for porous Ti fusion cage development,including microscale topology optimization based on homogenization theory that obtains a unit cell with prescribed mechanical properties,and macroscale topology optimization that determines the layout of framework structure over the porous cage while maintaining the desired *** biomechanical performance of the designed porous cage is assessed using numerical simulations of fusion *** laser melting is employed to assists with fabricating the designed porous structure and porous *** The simulations demonstrate that the designed porous cage increases the strain energy density of bone grafts and decreases the peak stress on bone *** mechanical and morphological discrepancies between the as-designed and fabricated porous structures are also *** From the perspective of biomechanics,it is demonstrated that the designed porous cage contributes to reducing the risk of stress shielding and cage *** optimization of processing parameters and post-treatments are required to fabricate the designed porous *** present multiscale optimization approach can be extended to the development of cages with other shapes or materials and further types of orthopedic implants.

主 题 词：Topology optimization Finite element method Porous fusion cage Lumbar spine Selective laser melting 

学科分类：0831[工学-公安技术类] 08[工学] 0836[0836] 

核心收录：

D　O　I：10.1007/s42242-021-00162-3

馆 藏 号：203106922...