Substitution for In Vitro and In Vivo Tests:Computational Models from Cell Attachment to Tissue Regeneration

作     者：Hao Huang Chaozong Liu Teng Yi Maryam Tamaddon Shanshan Yuan Zhenyun Shi Ziyu Liu 黄皓;刘朝宗;易腾;Maryam Tamaddon;苑姗姗;史震云;刘子钰

作者机构：School of Engineering MedicineUniversity College LondonRoyal National Orthopaedic HospitalStanmore HA74LPLondonUK Division of Surgery&Interventional ScienceUniversity College LondonRoyal National Orthopaedic HospitalStanmore HA74LPLondonUK National Institude of Defense Science and TechnologyBeijing 100071China School of Mechanical Engineering and AutomationBeihang University100191 BeijingChina Department of CardiologyQingdao Municipal HospitalQingdaoShandong 266071China 

基　　金：supported by the Versus Arthritis Research UK(Grant No:21977) European Commission via a H2020-MSCA-RISE programme(BAMOS,Grant No:734156) Innovative UK via Newton Fund(Grant No:102872) Engineering and Physical Science Research Council(EPSRC)via DTP CASE programme(Grant No:EP/T517793/1) 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2021年第36卷第4期

页      码：323-332页

摘      要：To get an optimal product of orthopaedic implant or regenerative medicine needs to follow trialand-error analyses to investigate suitable product’s material,structure,mechanical properites *** whole process from in vivo tests to clinical trials is expensive and *** model is seen as a useful analysis tool to make the product development.A series of models for simulating tissue engineering process from cell attachment to tissue regeneration are *** challenging is that models for simulating tissue engineering processes are developed *** cell to tissue regeneration,it would go through blood injection after moving out the defect;to cell disperse and attach on the scaffold;to proliferation,migration and differentiation;and to the final part-becoming mature *** paper reviewed models that related to tissue engineering process,aiming to provide an opportunity for researchers to develop a mature model for whole tissue engineering *** article focuses on the model analysis methods of cell adhesion,nutrient transport and cell proliferation,differentiation and migration in tissue *** cell adhesion model,one of the most accurate method is to use discrete phase model to govern cell movement and use Stanton-Rutland model for simulating cell *** for nutrient transport model,numerical model coupling with volume of fluid model and species transport model together is suitable for predicting nutrient transport *** cell proliferation,differentiation and migration,finite element method with random-walk algorithm is one the most advanced way to simulate these *** of the model analysis methods require further experiments to verify the accuracy and *** to the lack of technology to detect the rate of nutrient diffusion,there are especially few researches on model analysis methods in the area of blood ***,there is still a lot of work to be done in the resea

主 题 词：tissue engineering scaffold computer aided design computational fluid dynamics finite element models 

学科分类：10[医学] 

核心收录：

D　O　I：10.24920/004007

馆 藏 号：203107092...