Design,synthesis,and biological evaluation of a series of novel cordycepin derivatives

作     者：Lijuan Jiang Tingting Cao Ruoyi Yang Ying Li Lin Dong Shufan Yin 蒋丽娟;曹婷婷;杨诺一;李颖;董林;尹述凡

作者机构：College of ChemistrySichuan UniversityChengdu 610064SichuanChina School of Chemistry and Chemical EngineeringGuangxi University for NationalitiesGuangxi Key Laboratory for Polysaccharide Materials and ModificationsNanning 530008China 

基　　金：Research Basic Ability Enhancement Project of Young and Middle-aged Teachers in Guangxi Universities(Grant No.2019KY0166) the Project of Guangxi University for Nationalities(Grant No.2018MDYB006,2018XJGY46) 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2022年第31卷第1期

页      码：55-67页

摘      要：In this study,a novel series of cordycepin derivatives with benzenesulfonamido groups at the 6-position of the purine ring were synthesized and their antitumor activity was *** revealed the structural moieties of the cordycepin analogs that were required for antitumor *** all the target compounds,those with 4-methyl and 4-nitro substituents on the benzene ring displayed better activity than the lead compound in antiproliferative activity experiments using MDA-MB-231 and A549 ***,compounds with 4-methoxybenzene and 2-oxoindoline groups and ethylene spacers displayed more significant activity than the lead compound in antiproliferative activity experiments using He La *** particular,a compound with a 4-bromo substituent and an ethylene spacer displayed very high inhibitory activity against the proliferation of MDA-MB-231,A549,and He La cells,suggesting that it had the potential for further development and application.

主 题 词：Cordycepin Derivatives Synthesis Biological activity research 

学科分类：1007[医学-药学类] 10[医学] 

核心收录：

D　O　I：10.5246/jcps.2022.01.006

馆 藏 号：203107254...