Tracking morphologies at the nanoscale： Self-assembly of an amphiphilic designer peptide into a double helix superstructure
作者机构：Institute of Biophysics Medical University ofGraz BioTechMed-Graz 8010 Graz Austria Institute for Electron Microscopy and Nanoanalysis Graz University of Technology and Graz Centre for Electron Microscopy 80 10 Graz A us tria Institute of Inorganic Chemistry Graz University of Technology 8010 Graz Austria Institute of Organic Chemistry Graz University of Technology 8010 Graz Austria Institute for Molecular Biosciences KarI-Franzens-University Graz 8010 Graz Austria Research Unit Electron Microscopic Techniques Institute of Cell Biology Histology and Embryology Medical University of Graz 80 10 Graz A us tria Center for Medical Research Medical University of Graz 8010 Graz Austria
基 金：supported by the Austrian Science Fund (FWF Project) to R. P
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2015年第8卷第6期
页 码：1822-1833页
摘 要：Hierarchical self-assembly is a fundamental principle in nature, which gives rise to astonishing supramolecular architectures that are an inspiration for the development of innovative materials in nanotechnolog）a Here, we present the unique structure of a cone-shaped amphiphilic designer peptide. While tracking its concentration-dependent morphologies, we observed elongated bilayered single tapes at the beginning of the assembly process, which further developed into novel double-helix-like superstructures at high concentrations. This architecture is characterized by a tight intertwisting of two individual helices, resulting in a periodic pitch size over their total lengths of several hundred nanometers. Solution X-ray scattering data revealed a marked 2-layered internal organization. All these characteristics remained unaltered for the investigated period of almost three months. In their collective morphology, the assemblies are integrated into a network with hydrogel characteristics. Such a peptide-based structure holds promise as a building block for next-generation nanostructured biomaterials.
主 题 词：double helix amphiphilic designerpeptide self-assembl)~SAXS TEM spectroscopy
学科分类：0710[理学-生物科学类] 071010[071010] 081704[081704] 07[理学] 070205[070205] 08[工学] 0817[工学-轻工类] 080501[080501] 0805[工学-能源动力学] 0702[理学-物理学类]
核心收录：
D O I：10.1007/s12274-014-0683-9
馆 藏 号：203107423...
