Injectable bioactive polymethyl methacrylate-hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty

作     者：Xin Sun Xin Zhang Xin Jiao Jie Ma Xingzhen Liu Han Yang Kangping Shen Yaokai Gan Jinwu Wang Haiyan Li Wenjie Jin Xin Sun;Xin Zhang;Xin Jiao;Jie Ma;Xingzhen Liu;Han Yang;Kangping Shen;Yaokai Gan;Jinwu Wang;Haiyan Li;Wenjie Jin

作者机构：Shanghai Key Laboratory of Orthopaedic ImplantsDepartment of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Chemical and Environmental EngineeringSchool of EngineeringRMIT University124 La Trobe St.MelbourneVIC 3000Australia 

基　　金：supported by the National Key R&D Program of China(No.2018YFA0703000) the National Natural Science Foundation of China(Nos.82071564,82072412,and 81772326) the Fundamental Research Program Funding of Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(No.JYZZ070) Project of Shanghai Science and Technology Commission(No.19XD1434200/18431903700) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第2期

页      码：318-332页

摘      要：Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate *** improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid *** fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj *** addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and *** of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone *** study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP.

主 题 词：Polymethyl methacrylate bone cement Hydrogel Bone morphogenetic protein-2 Osteogenesis Percutaneous vertebroplasty 

学科分类：1002[医学-临床医学类] 100210[100210] 08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-021-00172-1

馆 藏 号：203108918...