4D printing of core-shell hydrogel capsules for smart controlled drug release

作     者：Shuo Zu Zhihui Zhang Qingping Liu Zhenguo Wang Zhengyi Song Yunting Guo Yuanzhu Xin Shuang Zhang Shuo Zu;Zhihui Zhang;Qingping Liu;Zhenguo Wang;Zhengyi Song;Yunting Guo;Yuanzhu Xin;Shuang Zhang

作者机构：Key Laboratory of Bionic EngineeringMinistry of EducationJilin UniversityChangchun 130025China School of Mechanical and Aerospace EngineeringJilin UniversityChangchun 130025China 

基　　金：supported by the National Key R&D Program of China(No.2018YFB1105100) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第2期

页      码：294-304页

摘      要：Personalized drugs,as well as disease-specific and condition-dependent drug release,have been highly desired in drug delivery systems for effective and safe ***-dimensional(4 D)printing,as a newly emerging technique to develop drug capsules,displays unique advantages that can autonomously control drug release according to the actual physiological ***,core-shell structured hydrogel capsules were developed using a multimaterial extrusion-based 4 D printing method,which consists of a model drug as the core and UV cross-linked poly(N-isopropylacrylamide)(PNIPAM)hydrogel as the *** to the lower critical solution temperature(LCST)-induced shrinking/swelling properties,the prepared PNIPAM hydrogel capsules showed temperature-responsive drug release along with the topography changes in the cross-linked PNIPAM *** in vitro drug release test confirmed that the PNIPAM hydrogel capsules can autonomously control their drug release behaviors according to changes in ambient ***,the increased shell thickness of these capsules causes an obvious reduction in drug release rate,distinctly indicating that the drug release behavior can be well adjusted by setting the shell thickness of the *** proposed 4 D printing strategy pioneers the paradigm of smart drug release by showing great potential in the smart controlled release of drugs and macromolecular active agents.

主 题 词：4D printing Hydrogel capsules Controlled release Poly(N-isopropylacrylamide)(PNIPAM) Personalized drugs 

学科分类：0831[工学-公安技术类] 100702[100702] 1007[医学-药学类] 1006[医学-中西医结合类] 100602[100602] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-021-00175-y

馆 藏 号：203109518...