3D-printed,bi-layer,biomimetic artificial periosteum for boosting bone regeneration

作     者：Yage Sun Ziwei Gao Xiaoping Zhang Ziyang Xu Yahan Zhang Binbin He Rong Yang Qian Zhang Qiang Yang Wenguang Liu Yage Sun;Ziwei Gao;Xiaoping Zhang;Ziyang Xu;Yahan Zhang;Binbin He;Rong Yang;Qian Zhang;Qiang Yang;Wenguang Liu

作者机构：School of Material Science and EngineeringTianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300350China Department of Spine SurgeryTianjin HospitalTianjin UniversityTianjin 300211China 

基　　金：the National Key Research and Development Program(No.2018YFA0703100) the National Natural Science Foundation of China(No.51733006) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2022年第5卷第3期

页      码：540-555页

摘      要：Periosteum,a membrane covering the surface of the bone,plays an essential role in maintaining the function of bone tissue—and especially in providing nourishment and vascularization during the bone regeneration ***,most artificial periostea have relatively weak mechanical strength and a rapid degradation rate,and they lack integrated angiogenesis and osteogenesis *** this study,a bi-layer,biomimetic,artificial periosteum composed of a methacrylated gelatin–nano-hydroxyapatite(GelMA-nHA)cambium layer and a poly(N-acryloyl 2-lycine)(PACG)-GelMA-Mg^(2+)fibrous layer was fabricated via 3D *** GelMA-nHA layer is shown to undertake the function of improving osteogenic differentiation of rat bone marrow mesenchymal stem cells with the sustainable release of Ca^(2+) from nHA *** hydrogen-bonding-strengthened P(ACG-GelMA-L)-Mg^(2+)hydrogel layer serves to protect the inner defect site and prolong degradation time(60 days)to match new bone ***,the released magnesium ion exhibits a prominent effect in regulating the polarization phenotype of macrophage cells into theM2 phenotype and thus promotes the angiogenesis of the human umbilical vein endothelial cells in *** bi-layer artificial periosteum was implanted into a critical-sized cranial bone defect in rats,and the 12-week post-operative outcomes demonstrate optimal new bone regeneration.

主 题 词：3D printing Bi-layer periosteum scaffold Immune regulation Bone regeneration 

学科分类：0831[工学-公安技术类] 08[工学] 0836[0836] 

核心收录：

D　O　I：10.1007/s42242-022-00191-6

馆 藏 号：203111439...