Fused deposition modeling 3D printed oral famotidine pulsatile release tablets

作     者：Rui Li Xiangyu Xu Di Chen Yue Zhang Haonan Qian Genao Zang Guangrong Yan Tianyuan Fan 李芮;徐翔宇;陈迪;张悦;钱浩楠;臧根奥;闫光荣;范田园

作者机构：The State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery SystemsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2022年第31卷第9期

页      码：657-664页

摘      要：The aim of this study was to prepare pulsatile release tablets which provide different drug delayed-release time and realize personalized administration according to the needs of *** deposition modeling(FDM)3D printing technology was introduced into the field of pharmaceutics in this study,and the feasibility to prepare core-shell pulsatile release tablets was explored by combing 3D printing technology with the traditional manufacturing *** core of the pulsatile tablets was a commercial tablet obtained from the traditional technology,and the drug-free shell was prepared by the FDM 3D printing *** kinds of tablet shells were designed using different ***,the morphology,size,weight,hardness,and in vitro drug release of the 3D printed famotidine pusatile tablets were characterized and *** results showed that the 3D printed tablets appeared intact without any *** parameters of outer shell affected the size,weight,hardness,and in vitro drug release of the *** tablets achieved a personalized delayed release time varying from 5 to 7 h in *** this way,a new method for preparing pulsatile release tablets and a new way for the personalized administration of pulsatile tablets were explored in this study.

主 题 词：FDM 3D printing Pulsatile release Oral preparation Famotidine 

学科分类：100702[100702] 1007[医学-药学类] 1006[医学-中西医结合类] 100602[100602] 10[医学] 

核心收录：

D　O　I：10.5246/jcps.2022.09.055

馆 藏 号：203114443...