Junction matters in hydraulic circuit bio-design of microfluidics

作     者：Yao Lin Dongliang He Zerui Wu Yurou Yao Zhanhao Zhang Yuheng Qiu Shan Wei Guangzhu Shang Xingyue Lei Ping Wu Weiping Ding Liqun He Yao Lin;Dongliang He;Zerui Wu;Yurou Yao;Zhanhao Zhang;Yuheng Qiu;Shan Wei;Guangzhu Shang;Xingyue Lei;Ping Wu;Weiping Ding;Liqun He

作者机构：Department of Thermal Science and Energy EngineeringUniversity of Science and Technology of ChinaHefei 230027China School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230027China GeneMind Biosciences Company LimitedShenzhen 518023China Department of Electronic Engineering and Information ScienceUniversity of Science and Technology of ChinaHefei 230027China 

基　　金：supported by the National Natural Science Foundation of China(Nos.31970754 and 82072018) the Strategic Priority Research Program(C)of the CAS(XDC07040200) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2023年第6卷第1期

页      码：38-50页

摘      要：Microfluidic channels are at micrometer scales;thus,their fluid flows are laminar,resulting in the linear dependence of pressure drop on flow rate in the length of the *** ratio of the pressure drop to flow rate,referred to as resistance,depends on channel size and dynamic ***,a microfluidic chip is analogous to an electric circuit in design,but the design is adjusted to optimize channel ***,whereas voltage loss is negligible at the nodes of an electric circuit,hydraulic pressure drops at the nodes of microfluidic chips by a magnitude are comparable to the pressure drops in the straight ***,we prove by experiment that one must fully consider the pressure drops at nodes so as to accurately design a precise microfluidic *** the process,we numerically calculated the pressure drops at hydraulic nodes and list their resistances in the range of flows as *** resorted to machine learning to fit the calculated results for complex ***,we obtained a library of node resistances for common junctions and used them to design three established chips that work for single-cell analysis and for precision allocation of solutes(in gradient and averaging concentration microfluidic networks).Endothelial cells were stimulated by generating concentrations of adriamycin hydrochloride from the last two microfluidic networks,and we analyzed the response of endothelial *** results indicate that consideration of junction resistances in design calculation brings experimental results closer to the design values than *** approach may therefore contribute to providing a platform for the precise design of organ chips.

主 题 词：Junctions Hydraulics Microfluidic chip design 

学科分类：0831[工学-公安技术类] 08[工学] 0836[0836] 

核心收录：

D　O　I：10.1007/s42242-022-00215-1

馆 藏 号：203115677...