Designs andmethodologies to recreate in vitro human gutmicrobiota models

作     者：Francesco Biagini Costanza Daddi Marco Calvigioni Carmelo De Maria Yu Shrike Zhang Emilia Ghelardi Giovanni Vozzi Francesco Biagini;Costanza Daddi;Marco Calvigioni;Carmelo De Maria;Yu Shrike Zhang;Emilia Ghelardi;Giovanni Vozzi

作者机构：Research Center(E.Piaggio)University of PisaPisaItaly Department of Information EngineeringUniversity of PisaPisaItaly Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly Division of Engineering in MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMAUSA 

基　　金：supported by the BIOMEMBRANE project (M-ERA.net 2 project 4246) the KERAPACK project (MANUNET MNET 17/NMAT-0060) the PRA_2018_68 (grant supported by the University of Pisa) MIT-UNIPI project (grant supported by the University of Pisa and the MIT) the support of the Additive Manufacturing Cross-Lab of the Department of Information Engineering of the University of Pisa 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2023年第6卷第3期

页      码：298-318页

摘      要：The human gut microbiota is widely considered to be a metabolic organ hidden within our bodies,playing a crucial role in the host’s *** factors affect its composition,so a wide variety of microbes residing in the gut are present in the world *** excessive imbalances in microbial composition are often associated with human disorders and pathologies,and new investigative strategies to gain insight into these pathologies and define pharmaceutical therapies for their treatment are *** vitro models of the human gut microbiota are commonly used to study microbial fermentation patterns,community composition,and host-microbe *** and microfluidic devices have been designed to culture microorganisms from the human gut microbiota in a dynamic environment in the presence or absence of eukaryotic cells to interact *** this review,we will describe the overall elements required to create a functioning,reproducible,and accurate in vitro culture of the human gut *** addition,we will analyze some of the devices currently used to study fermentation processes and relationships between the human gut microbiota and host eukaryotic cells.

主 题 词：Gut microbiota In vitro models Bioreactors Host-microbiome Fermentation 

学科分类：0710[理学-生物科学类] 1007[医学-药学类] 100705[100705] 1002[医学-临床医学类] 1001[医学-基础医学] 100103[100103] 0836[0836] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-022-00210-6

馆 藏 号：203118231...