肠道外补充的谷氨酰胺减少了低出生体重儿全身蛋白水解作用

作     者：Kalhan S.C. Parimi P.S. Gruca L.L. Hanson R.W. 李丹 

作者机构：Schwartz Ctr. for Metab. and Nutr. 2500 Metro Health Dr Cleveland OH 44109-1998 United States 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第10期

页      码：55-56页

摘      要：Objectives: To examine the effect of supplemental glutamine (0.6 *** -1.d-1 ) on whole body protein/nitrogen and glutamine kinetics in low birth weight (LBW ) infants receiving parenteral nutrition in the immediate neonatal period. Study design: Premature infants ≤32 weeks gestation with a birth weight from 694 to 1590 g were randomly assigned to either a glutamine supplemented group (n = 10) or to a control group (n = 10). Tracer isotope studies were performed when the i nfants were 6 to 7 days old and had been receiving an amino acid intake of appro ximately 3.0 *** -1.d-1 for at least 3 days. Whole body glutamine and nitroge n kinetics were measured with [5-15N]glutamine, [ 2H5]phenylalanine, [1-13C, 1 5N] leucine, [15N2]urea, and GC-mass spectrometry. Results: Supplemental glutam ine was associated with a lower rate of appearance of glutamine (P = .003), phen ylalanine (P = .001), and leucine C (P = .003). There was no significant differe nce in leucine N turnover, urea turnover and plasma cortisol, and C-reactive pr otein levels in the 2 groups. Conclusion: Parenteral glutamine supplement in LBW infants was associated with lower wholebody protein breakdown. Because the decr ease in whole body proteolysis is associated with protein accretion, parenteral glutamine supplement may be beneficial in selected populations of LBW infants.

主 题 词：蛋白水解 肠道外营养 新生儿期 尿素循环 动力学测定 光谱测定法 同位素研究 研究设计 分解率 中肠 

学科分类：1002[医学-临床医学类] 100202[100202] 10[医学] 

馆 藏 号：203120312...