Use of N,O-carboxymethyl chitosan to prevent postsurgical adhesions in a rabbit double uterine horn model： a randomized controlled design

作     者：Chang Ren Dachun Zhao Lan Zhu 

作者机构：Departments of Obstetrics & Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beiiing 100730 China Departments of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2016年第59卷第5期

页      码：504-509页

摘      要：In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.

主 题 词：postsurgical adhesion adhesion prevention N O-carboxymethyl chitosan rabbit double uterine horn model random-ized controlled trial 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

核心收录：

D　O　I：10.1007/s11427-016-5019-4

馆 藏 号：203120756...