使用低分子量肝素预防血栓形成和妊娠的关系:两项随机对照试点研究

作     者：Gates S. Brocklehurst P. Ayers S. Bowler U. 李宁 

作者机构：National Perinatal Epidemiology Unit University of Oxford Oxford United Kingdom 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第3期

页      码：13-14页

摘      要：Objective The purpose of this study was to conduct pilot studies for large randomized controlled trials to compare low molecular weight heparin with placebo for antenatal thromboprophylaxis (trial 1), and for thromboprophylaxis after cesarean delivery (trial 2). Study design Multicenter randomized controlled trials (trial 1, 23 units; trial 2, 8 units) were conducted. Pregnant women at increased risk for thromboembolic disease were eligible for trial 1; women who underwent cesarean delivery were eligible for trial 2. The interventions were once daily injections of low molecular weight heparin or placebo. Primary outcomes were as follows: trial 1, confirmed symptomatic thromboembolic events and symptomatic osteoporotic fractures; trial 2, confirmed symptomatic thromboembolic events and wound complications. Results Sixteen women were recruited for trial 1; 1 woman in the placebo group had a symptomatic thromboembolic event. One hundred forty one women were recruited for trial 2; 1 woman in the low molecular weight heparin group had a symptomatic thromboembolic event. Conclusion Poor recruitment indicates that large scale trials using these designs would be difficult. Collection of data on the number of women that are eligible and the reasons for nonrecruitment in future trials of these interventions would allow a better understanding of the reasons for poor recruitment.

主 题 词：低分子量肝素 血栓形成 试点研究 剖宫产术 随机对照试验 高危孕妇 随机对照方法 安慰剂 骨质疏松性骨折 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

馆 藏 号：203120875...