人类早孕期胎盘灌注与PlGF蛋白表达的关系

作     者：Welch P.C. Amankwah K.S. Miller P. M.E. McAsey 朱磊 

作者机构：Department of Obstetrics and Gynecology Southern Illinois University School of Medicine Springfield IL United States Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第11期

页      码：5-5页

摘      要：Objective: The purpose of this study was to investigate temporal correlations between maternal serum placenta growth factor levels and placental perfusion in early human pregnancies. Study design: Systolic umbilical artery Doppler blood flow velocity indices at fetal and placental insertion sites were measured between 7 and 22 weeks of gestation from normal singleton pregnancies. Maternal serum placenta growth factor levels were determined by enzyme-linked immunosorbent assay. Results: Maternal serum placenta growth factor levels showed an exponential increase at approximately 14 weeks of gestation. Placenta perfusion, as estimated by systolic Doppler blood flow indices, significantly increased with gestational age (P < .000 1). There was a close association between placenta growth factor expression levels and evidence of increased placenta perfusion (P < .033). Conclusion: The significant increase in serum placenta growth factor coincides with the increased perfusion of the maternal/fetal interface at approximately 12 to 14 weeks of gestation. Correlation of placenta growth factor expression and placental perfusion suggests that placenta growth factor may contribute to assuring adequate vascular development/function of the placenta early in gestation.

主 题 词：早孕期 PlGF蛋白 脐动脉收缩期 多普勒血流速度 妊娠早期 指数增长 血管生长 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

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