Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

作     者：Xinshuo Huang Baoming Liang Shantao Zheng Feifei Wu Mengyi He Shuang Huang Jingbo Yang Qiangqiang Ouyang Fanmao Liu Jing Liu Hui-jiuan Chen Xi Xie Xinshuo Huang;Baoming Liang;Shantao Zheng;Feifei Wu;Mengyi He;Shuang Huang;Jingbo Yang;Qiangqiang Ouyang;Fanmao Liu;Jing Liu;Hui-jiuan Chen;Xi Xie

作者机构：State Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhou 510006China School of Biomedical EngineeringSun Yat-Sen UniversityShenzhen 518107China Pazhou LabGuangzhou 510330China The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510006China 

基　　金：This work was financially supported by the National Key R&D Program of China(Nos.2021YFF1200700 and 2021YFA0911100) the National Natural Science Foundation of China(Nos.32171399,32171456,and T2225010) the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515012261) the Science and Technology Program of Guangzhou,China(No.202103000076) the Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(No.22dfx02),and Pazhou Lab,Guangzhou(No.PZL2021KF0003) FML would like to thank the National Natural Science Foundation of China(Nos.32171335 and 31900954) JL would like to thank the National Natural Science Foundation of China(No.62105380) the China Postdoctoral Science Foundation(No.2021M693686) QQOY would like to thank the China Postdoctoral Science Foundation(No.2022M713645) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第1期

页      码：14-30页

摘      要：Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

主 题 词：Microarrow sensor array Glucose sensing Reactive oxygen species sensing Integrated system Continuous monitoring 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 1002[医学-临床医学类] 1001[医学-基础医学] 08[工学] 0703[理学-化学类] 0836[0836] 

核心收录：

D　O　I：10.1007/s42242-023-00246-2

馆 藏 号：203124395...