Rapid printing of 3D porous scaffolds for breast reconstruction

作     者：Pengcheng Zhao Biling Wang Lu Wang Zexin Fu Jun Hu Yande Liu Ji Wang Yong He Pengcheng Zhao;Biling Wang;Lu Wang;Zexin Fu;Jun Hu;Yande Liu;Ji Wang;Yong He

作者机构：School of Mechatronics and Vehicle EngineeringEast China Jiaotong UniversityNanchang 330013China Center for Plastic and Reconstructive SurgeryDepartment of Plastic and Reconstructive SurgeryZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China Key Laboratory of 3D Printing Process and Equipment of Zhejiang ProvinceSchool of Mechanical EngineeringZhejiang UniversityHangzhou 310027China 

基　　金：This work was supported by the National Key Research andDevelopment Program of China(No.2018YFA0703000) the National Natural Science Foundation of China(Nos.T2121004,52235007,and 82203602) Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ22H160020 to JW This work was also supported by Start-up Funding of Zhejiang Provincial People’s Hospital(No.ZRY2021A001 to JW) Basic Scientific Research Funds of Department of Education of Zhejiang Province(No.KYQN202109 to JW) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造(英文))

年 卷 期：2023年第6卷第6期

页      码：691-703页

摘      要：Prosthesis implantation and fat transplantation are common breast *** general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct *** date,no reports have focused on methods of combining fat with implanted prostheses for breast *** a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous *** was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external *** compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural ***,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose *** were implanted subcutaneously in nude mice to observe their biological *** 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the *** result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.

主 题 词：Projection-based 3D bioprinting(PBP) F127DA Breast reconstruction Fat transplantation 

学科分类：0831[工学-公安技术类] 1001[医学-基础医学] 10[医学] 

核心收录：

D　O　I：10.1007/s42242-023-00253-3

馆 藏 号：203124453...