Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

作     者：Shuang Huang Shantao Zheng Mengyi He Chuanjie Yao Xinshuo Huang Zhengjie Liu Qiangqiang Ouyang Jing Liu Feifei Wu Hang Gao Xi Xie Hui-jiuan Chen Shuang Huang;Shantao Zheng;Mengyi He;Chuanjie Yao;Xinshuo Huang;Zhengjie Liu;Qiangqiang Ouyang;Jing Liu;Feifei Wu;Hang Gao;Xi Xie;Hui-jiuan Chen

作者机构：State Key Laboratory of Optoelectronic Materials and TechnologiesGuangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical InstrumentSchool of Biomedical EngineeringSun Yat-Sen UniversityShenzhen 518107China The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Pazhou LabGuangzhou 510335China Institute of Microelectronics of the Chinese Academy of SciencesBeijing 100029China 

基　　金：The authors would like to acknowledge financial support from the National Key R&D Program of China(Nos.2021YFF1200700 and 2021YFA0911100) the National Natural Science Foundation of China(Nos.T2225010,32171399,and 32171456) the Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(No.22dfx02) Pazhou Lab,Guangzhou(No.PZL2021KF0003) The authors also would like to thank the funding support from the Opening Project of Key Laboratory of Microelectronic Devices&Integrated Technology,Institute of Microelectronics,Chinese Academy of Sciences,and State Key Laboratory of Precision Measuring Technology and Instruments(No.pilab2211) QQOY would like to thank the China Postdoctoral Science Foundation(No.2022M713645) JL would like to thank the National Natural Science Foundation of China(No.62105380)and the China Postdoctoral Science Foundation(No.2021M693686) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第1期

页      码：88-103页

摘      要：Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

主 题 词：Multiplexed microfilament electrode cluster Physiological ion sensing Subcutaneous and brain experiment Wearable platform for multi-ion detection Continuous real-time monitoring system 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 0808[工学-自动化类] 1001[医学-基础医学] 0809[工学-计算机类] 08[工学] 100102[100102] 0804[工学-材料学] 0836[0836] 

核心收录：

D　O　I：10.1007/s42242-023-00262-2

馆 藏 号：203125229...