Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

作     者：Anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Anil A.Acar;Evangelos Daskalakis;Paulo Bartolo;Andrew Weightman;Glen Cooper;Gordon Blunn;Bahattin Koc

作者机构：Faculty of Engineering and Natural SciencesSabanci UniversityIstanbul 34956Türkiye D Bioprinting LaboratorySabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of MechanicalAerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D PrintingSchool of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical SciencesUniversity of PortsmouthPortsmouth PO12UPUK 

基　　金：supported by the Engineering and Physical Sciences Research Council (EPSRC) of the UK the Global Challenges Research Fund (GCRF) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第1期

页      码：74-87页

摘      要：Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

主 题 词：Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds 

学科分类：08[工学] 0831[工学-公安技术类] 0710[理学-生物科学类] 1002[医学-临床医学类] 1001[医学-基础医学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 0813[工学-化工与制药类] 0836[0836] 0814[工学-地质类] 0812[工学-测绘类] 0702[理学-物理学类] 

核心收录：

D　O　I：10.1007/s42242-023-00259-x

馆 藏 号：203125267...