在儿科三级保健医院内囊性纤维病是复发性静脉血栓形成的危险因素

作     者：Raffini L.J. Raybagkar D. Blumenstein M.S. 贺莉 

作者机构：Divisions of Hematology and Pulmonary MedicineThe Children's Hospital of PhiladelphiaDepartment of PediatricsPhiladelphiaUnited States Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第12期

页      码：32-33页

摘      要：Objective:To evaluate risk factors for recurrent thrombosis in pediatric patients. Study design:This prospective observational cohort study enrolled 120 patients with acute venous thromboembolism from January 2003 to April 2005. Datacollection included medical and family history,radiologic and laboratory studies,therapy,and follow-up. Results:The overall prevalence of recurrent thrombosis in our cohort was 19/120(15.8%). Patients with recurrence were older,with a median age of 14.8 years (range 2 weeks-23.6 years),compared with 10.1years (range newborn 23.4 years) in patients without recurrence(P = 0.03). Six of the 19 patients with recurrent thrombosis had cystic fibrosis (CF),compared with 0/101without recurrence (P< 0.001). Five of these 6 patients were colonized with Burkholderia cepacia in their sputum. Central venous catheters were associated with most,but not all,of the thromboses in patients with CF. Conclusions:In this study,patients with CF had a high risk of recurrent venous thrombosis,as well as a high prevalence of colonization with B cepacia. The cause of this risk has not been defined. This observation may have important implications for thromboprophylaxis,particularly in the setting of central venous catheters.

主 题 词：囊性纤维病 静脉血栓形成 队列研究 前瞻性观察 中心静脉插管 伯克霍尔德 试验设计 

学科分类：1002[医学-临床医学类] 100202[100202] 10[医学] 

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