An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

作     者：Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Seol-Ha Jeong;Jarno Hiemstra;Patrick V.Blokzijl;Rebeca Damian-Ferrara;Danilo Martins dos Santos;Jéssica H.L.da Fonseca;Min-Ho Kang;Jihyun Kim;Dilara Yilmaz-Aykut;Mei L.L.Cham-Pérez;Jeroen Leijten;Su Ryon Shin

作者机构：Division of Engineering in MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten LabDepartment of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA)Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical EngineeringThe Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of BiotechnologyThe Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea 

基　　金：funded by the National Insti-tutes of Health(No.R01 AR074234) AHA collaborative award(No.944227) the Gillian Reny Stepping Strong Center for Trauma Inno-vation at Brigham and Women's Hospital 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第3期

页      码：240-261页

摘      要：Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

主 题 词：3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle 

学科分类：0831[工学-公安技术类] 08[工学] 0836[0836] 

核心收录：

D　O　I：10.1007/s42242-024-00281-7

馆 藏 号：203127915...