Single-cell multi-omics analysis revealing immune features of inactivated COVID-19 vaccination in systemic lupus erythematosus patients

作     者：Yuxuan Zheng Siyuan Wang Xingyu Zhou Shitong Qiao Xin Zhao Yuan Chen Zijun Li Zhanguo Li Xiaolin Sun Shuguang Tan Jing He George Fu Gao 郑宇轩;王思远;周星宇;乔世橦;赵欣;陈缘;李子君;栗占国;孙晓麟;谭曙光;何菁;高福

作者机构：CAS Key Laboratory of Pathogen Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Department of Rheumatology and ImmunologyPeking University People’s HospitalBeijing Key Laboratory for Rheumatism and Immune Diagnosis(BZ0135)Beijing 100044China Medical SchoolUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100871China 

基　　金：supported by the National Key Research and Development Program of China(2022YFC2604100,2022YFC2302900,2021YFC2301400,and 2022YFE0131700) National Natural Science Foundation of China(92169208,32222031,82071813,32141004,and 82171775) Peking University People’s Hospital Research and Development Funds(RDGS2022-05) National Postdoctoral Program for Innovative Talents of China(BX20220332) 

出 版 物：《Science Bulletin》 (科学通报(英文版))

年 卷 期：2025年第70卷第1期

页      码：42-46页

摘      要：Studies have focused on neutralizing antibody titers and T-cell activation induced by vaccination against different SARS-CoV-2strains[1,2].Advanced single-cell technology has allowed for a comprehensive evaluation of immune responses to diverse vaccines,revealing potential antiviral mechanisms[3-5].Patients with rheumatic diseases(RDs)experience dysregulated cellular and humoral immune responses that affect their disease susceptibility,including COVID-19[6].

主 题 词：vaccination revealing titer 

学科分类：1004[医学-公共卫生预防医学类] 1002[医学-临床医学类] 100201[100201] 100401[100401] 10[医学] 

核心收录：

D　O　I：10.1016/j.scib.2024.05.038

馆 藏 号：203128136...