Design,synthesis and biological estimation of 1-(benzoxazole-2-yl)piperazine and 4-(benzoxazole-2-yl)piperidine derivatives as potentialα_1-AR antagonists

作     者：Jia Bin Li Lin Xia Bin Wu Tao Wang Zhen Zhou Jiang 

作者机构：Department of Inorganic Chemistry China Pharmaceutical University Nanjing 210009 China Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China National Drug Screening Center China Pharmaceutical University Nanjing 210009 China School of Pharmacy Nanjing Medical University Nanjing 210029 China 

基　　金：the National High-Tech Research and Development Plan(No.2002AA2Z3118) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第10期

页      码：1193-1195页

摘      要：Two series of 1-（benzoxazole-2-yl）piperazine （Sa-i） and 4-（benzoxazole-2-yl）piperidine compounds （10a-i） were designed, synthesized and evaluated for their α1-AR antagonistic activities. Biological assay in vitro indicated that 10h showed slightly stronger α1-AR antagonistic activity to that of our lead compound 1.

主 题 词：BPH α1-AR antagonists Benzoxazole Piperidine Piperazine 

学科分类：081704[081704] 07[理学] 070304[070304] 08[工学] 0817[工学-轻工类] 0703[理学-化学类] 

核心收录：

D　O　I：10.1016/j.cclet.2008.06.042

馆 藏 号：203128618...