在早产新生儿动脉导管未闭的处理中应用床旁测定生物标志物血浆B型钠尿肽

作     者：Flynn P.A. Da Graca R.L. Auld P.A.M. 郭战宏 

作者机构：Division of Pediatric Cardiology F- 695B Weill- Cornell Center New York-Presbyterian Hospital 525 East 68th Street New York NY 10021 United StatesDr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第12期

页      码：31-32页

摘      要：To test the utility of the bedside plasma concentration of B-type natriuretic peptide (BNP) assay as a screen for patent ductus arteriosus (PDA) in premature neonates. Study design: Newborn infants admitted to the neonatal intensive care unit (NICU) had paired echocardiography and BNP measurements at enrollment and every 4 to 5 days. Results: Twenty neonates (gestational age ～ 28.6 weeks and birthweight ～ 1161 g) had 81 paired echocardiography and BNP determinations. BNP ranged from 5 to 3900 pg/mL. Fifty-six of 81 echocardiograms showed PDA. Significant correlations were found between BNP and ductal size and degree of shunting. Correlation was greater in infants >2 days of age. BNP >300 pg/mL predicted significant PDA, whereas BNP < 105 pg/mL predicted absence of significant PDA. Conclusion: Bedside measurement of BNP correlates with magnitude of PDA in premature newborns, particularly beyond day 2, and may be useful in guiding diagnostic and management strategies.

主 题 词：早产新生儿 B型钠尿肽 脑钠尿肽 生物标志物 心脏超声检查 研究设计 

学科分类：1002[医学-临床医学类] 100202[100202] 10[医学] 

馆 藏 号：203128979...