极低出生体重新生儿口服肠道益生菌预防坏死性小肠结肠炎

作     者：Bin-Nun A. Bromiker R. Wilschanski M. C. Hammerman 王一飞 

作者机构：Department of Neonatology Shaare Zedek Medical Center POB 3235 Jerusalem 91031 Israel Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第1期

页      码：28-28页

摘      要：Objective: To test the hypothesis that normalizing the intestinal flora by adm inistration of prophylactic probiotics would provide a natural defense, thereby reducing both the incidence and severity of necrotizing enterocolitis (NEC) in p reterm neonates. Study design: Neonates ≤1500 g birth weight were randomized to either receive a daily feeding supplementation with a probiotic mixture (Bifido bacteria infantis, Streptococcus thermophilus, and Bifidobacteria bifidus; Solga r, Israel) of 109 colony forming units (CFU)/day or to not receive feed suppleme nts. NEC was graded according to Bell’s criteria. Results: For 72 study and 73 control infants, respectively, birth weight (1152 ±262 g vs 1111 ±278 g), gest ational age (30 ±3 weeks vs 29 ±4 weeks), and time to reach full feeds (14.6 ±8.7 days vs 17.5 ±13.6 days) were not different. The incidence of NEC was red uced in the study group (4%vs 16.4%; P = .03). NEC was less severe in the prob iotic-supplemented infants (Bell’s criteria 2.3 ±0.5 vs 1.3 ±0.5; P = .005). Three of 15 babies who developedNEC died, and all NEC-related deaths occurred in control infants. Conclusion: Probiotic supplementation reduced both the incid ence and severity of NEC in our premature neonatal population.

主 题 词：肠道益生菌 菌落形成单位 预防性使用 混合喂养 嗜热链球菌 肠道菌群 研究设计 

学科分类：1002[医学-临床医学类] 100202[100202] 10[医学] 

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