运用无中心腔的支架进行胆汁引流:一项先导性研究

作     者：Raju G.S. Sud R. Elfert A.A. P.J. Pasricha 郝筱倩 

作者机构：4.106 McCullough Bldg. University of Texas Medical Branch 301 University Blvd Galveston TX 77555-0764 United States Dr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2006年第2卷第5期

页      码：40-41页

摘      要：Abstract Abstract Background: Despite several attempts to make the conventional tubular stents with a central lumen for flow less susceptible to a biofilm buildup and thereby prevent clogging, this goal has remained elusive. We hypothesized that the creation of pathways for fluid flow around the stent instead of through it would avoid this problem. The aim of our study was to report the development and the evaluation of a novel lumen-less stent. Methods: By using a software computer modeling, a 10F “ winged" stent was designed. A pilot feasibility study was performed by using a prototype of this stent for endoscopic biliary drainage in 5 patients with malignant biliary obstruction. Observations: Modeling data revealed that the winged stent offers a larger surface area for flow, higher velocity of flow, and increased flow rates compared with the conventional tubular stent. In the clinical trial, there was a significant decrease of serum bilirubin after the placement of this stent (serum bilirubin before and 2 weeks after stent placement, 14.94 ± 5.7 mg/dL vs. 2.86 ± 1.4 p < 0.004 ), accompanied by radiologic evidence of decompression of the biliary system. Conclusions: We have shown that it is possible to provide adequate biliary drainage by using a stent without a lumen. Such a design may have potential clinical advantages over existing designs.

主 题 词：支架设计 胆汁引流 先导性 血清胆红素 心腔 计算机软件 生物被膜 试验研究 胆管阻塞 接触面积 

学科分类：1003[医学-口腔医学类] 1002[医学-临床医学类] 100210[100210] 100302[100302] 10[医学] 

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