The unexpected“butterfly effect”of Pt-coordinated cyanine self-assembly for enhanced tumor photothermal therapy

作     者：Erting Feng Fangyuan Lv Shanliang Tang Jianjun Du Shibo Lv Yingnan Wu Dapeng Liu Panwang Zhou Fengling Song Xiaojun Peng 冯二厅;吕方圆;汤善亮;杜健军;吕世博;吴蓥男;刘大鹏;周潘旺;宋锋玲;彭孝军

作者机构：State Key Laboratory of Fine ChemicalsFrontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian116024China Institute of Frontier ChemistrySchool of Chemistry and Chemical EngineeringShandong UniversityQingdao266237China Institute Shenzhen Research Institute of Shandong UniversityShenzhen518057China 

基　　金：supported financially by Guangdong Basic and Applied Basic Research Foundation(2019A1515110441) the Natural Science Foundation of Shandong Province(ZR2020QB001) the National Key Research and Development Program of China(2023YFC3403000) the National Natural Science Foundation of China(22378231 and 22001148) 

出 版 物：《Science China Materials》 (中国科学（材料科学）（英文版）)

年 卷 期：2024年第67卷第9期

页      码：3003-3011页

摘      要：J-aggregates of cyanine have shown great merits in tumor photothermal therapy(PTT)due to their distinct redshift absorption as well as superior photothermal conversion efficiency(PCE).However,due to the complexity of intermolecular interactions,especially the impact of steric hindrance on aggregation,exploring effective strategies to regulate the aggregation modes of organic materials remains ***,steric hindrance-regulated J-aggregation of near-infrared(NIR)cyanine was reported based on Pt-coordinated cyanine self-assembly with unexpected“butterfly effect”.Two Pt-coordinated cyanine dimers CyR-Pt(R=Me and Et)were synthesized and spontaneously self-assembled into aggregates in aqueous ***-Pt aggregates were loose and amorphous *** replacing ethyl with methyl to reduce steric hindrance,a tiny change resulted in the generation of tightly stacked cyanine J-aggregates(thickness less than 3 nm)observed in CyMe-Pt ***,this unexpected“butterfly effect”enabled CyMe-Pt J-aggregates to effectively inhibit reactive oxygen species and greatly improve its ***,CyMe-Pt J-aggregates with NIR-II absorption exhibited outstanding photothermal stability and higher PCE(η=37%)than CyEt-Pt disordered aggregates(η=20%).Evident tumor suppression performance of CyMe-Pt J-aggregates was validated under 980 nm laser irradiation,demonstrating its great potential in tumor PTT.

主 题 词：near-infrared cyanine metal coordination steric hindrance J-aggregation photothermal therapy 

学科分类：1002[医学-临床医学类] 100214[100214] 10[医学] 

核心收录：

D　O　I：10.1007/s40843-024-2976-8

馆 藏 号：203131456...