Synthesis of novel ADPR analogues: substitution of pyrophosphate linkage by dipeptide

作     者：张超 杨振军 张亮仁 张礼和 Chao Zhang;Zhen-Jun Yang;Liang-Ren Zhang;Li-He Zhang

作者机构：北京大学药学院天然药物及仿生药物国家重点实验室北京100083 

基　　金：National Natural Science Foundation of China(Grant No.20472007) the Research Found for the DocroralProgram of Higher Education 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2007年第16卷第4期

页      码：262-267页

摘      要：For investigating the biological function of ADPR, four novel analogues （compounds 2-5） in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide were synthesized. 5＇-Amino adenosine or its analogues was used as the starting material, liquid phase peptide synthesis strategy was used to construct these ADPR analogues. The structures were characterized by 1H NMR and HRMS spectra. This study provides a versatile synthesis of peptide modified ADPR analogues and helps to understand the structure-activity relationship of ADPR.

主 题 词：ADPR Nucleoside Analogues Synthesis 

学科分类：1007[医学-药学类] 100701[100701] 10[医学] 

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