Design, Synthesis and Biological Activity of Novel Chalcone Derivatives as Anti-influenza Agents

作     者：SHI Fangyuan FANG Hao XU Wenfang 

作者机构：Department of Medicinal Chemistry School of Pharmaceutical Sciences Shandong University Jinan 250012 P. R. China 

基　　金：Supported by the National High-tech R&D Program of China(No.2014AA020523)  the National Natural Science Foundation of China(Nos.21302111  81373282  21172134) and the China Postdoctoral Science Foundation Funded Project (Nos.2013M540558  2014T70654) 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2016年第32卷第1期

页      码：28-34页

摘      要：A series of novel chalcone derivatives was designed and synthesized via a suitable synthetic strategy in good yields using commercially available 2-amino-4-nitrophenol as an initiator. The structures of the target compounds were confirmed by means of IH NMR, 13C NMR and high-resolution mass spectrometry（HRMS）. And the ability of the target compounds to inhibit influenza viruses was evaluated. These compounds showed moderate inhi- bitory activity against influenza A（H9N2 and H5NI） viruses. Within this series, compounds S14 and S15 with good potency（IC50=40.3--51.5 μmol/L） could be used as lead compounds in the future.

主 题 词：Influenza virus Inhibitor Chalcone Biological activity 

学科分类：1007[医学-药学类] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 10[医学] 

核心收录：

D　O　I：10.1007/s40242-015-5356-z

馆 藏 号：203133576...