Rapid fabrication of modular 3D paper-basedmicrofluidic chips using projection-based 3D printing

作     者：Mingjun Xie Zexin Fu Chunfei Lu Sufan Wu Lei Pan Yong He Yi Sun Ji Wang 

作者机构：Plastic and Reconstructive Surgery CenterDepartment of Plastic and Reconstructive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China State Key Laboratory of Fluid Power and Mechatronic SystemsSchool of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Key Laboratory of Materials Processing and MoldZhengzhou UniversityZhengzhou 450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang ProvinceCollege of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Cancer CenterZhejiang UniversityHangzhou 310058China 

基　　金：sponsored by the National Natural Science Foundation of China(No.52235007,YH) the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004,YH) the NationalNatural Science Foundation of China(No.52305300,MJX) the Fellowship of China Postdoctoral Science Foundation(No.2022M722826,MJX) the National Natural Science Foundation of China(No.82203602,JW) the Zhejiang Provincial Natural Science Foundation of China(No.LQ22H160020,JW) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第5期

页      码：611-623页

摘      要：Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other *** study describes amethod developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and *** evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally ***,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel ***-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be ***,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paperbased microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.

主 题 词：Paper-based microfluidic chip Projection-based 3D printing(PBP) Modularization Cell culture 

学科分类：08[工学] 0813[工学-化工与制药类] 0814[工学-地质类] 0811[工学-水利类] 0812[工学-测绘类] 

核心收录：

D　O　I：10.1007/s42242-024-00298-y

馆 藏 号：203136674...