Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent

作     者：Xiao Zhong Fu Sai Hong Jiang Jian Xin Yu She Yang RU Yun Ji 

作者机构：School of Pharmacy Guiyang Medical College Guiyang 550004 China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological SciencesChinese Academy of Science Shanghai 201203 China Shanghai Fudan-Yueda Bio-Tech Co. Ltd. Shanghai 201203 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第7期

页      码：817-819页

摘      要：A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 μmol/L and 2530 μmol/L, respectively.

主 题 词：Acyclic nucleoside phosphonates L-Amino acid Prodrug Anti-HBV activity 

学科分类：1007[医学-药学类] 1004[医学-公共卫生预防医学类] 100401[100401] 100701[100701] 10[医学] 

核心收录：

D　O　I：10.1016/j.cclet.2007.05.013

馆 藏 号：203138324...