Histone variants: the artists of eukaryotic chromatin

作     者：LI Min FANG YuDa 

作者机构：National Key Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 

基　　金：supported by the National Natural Science Foundation of China(31171168 and 91319304) National Basic Research Program of China(2012CB910503) 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2015年第58卷第3期

页      码：232-239页

摘      要：The eukaryotic genome is packaged into a complex nucleoprotein structure named chromatin, balancing the compactness of genome and the accessibility of regulatory proteins and RNA polymerases to DNA. The mechanisms of the regulation of chromatin dynamics include the post-translational modification of histones, alteration of nucleosome positions by chromatin remodelers, replacement of canonical histones by histone variants with the aid of histone chaperones, and dynamic organization of the three-dimensional genome in the small nucleus. Histone variants are different from canonical histones by substitution of several amino acid residues or changes in amino acid sequence. Histone variants perform specialized functions such as altering nucleosome stability, dynamics, structure, as well as playing critical roles in a range of biological processes like transcriptional regulation, DNA repair and recombination, development and immune responses. Here we discuss how histone variants, their modification and specific loading to chromatin are involved in transcriptional regulation, DNA repair and plant development.

主 题 词：组蛋白 染色质 变体 艺术家 DNA修复 真核 核基因组 RNA聚合酶 

学科分类：0710[理学-生物科学类] 0830[工学-生物工程类] 07[理学] 09[农学] 071007[071007] 0901[农学-植物生产类] 090102[090102] 

核心收录：

D　O　I：10.1007/s11427-015-4817-4

馆 藏 号：203140780...