Comprehensive Understanding of Immune Cells in The Pathogenesis of Non-alcoholic Fatty Liver Disease

作     者：OUYANG Fei-Fan RASHEED Madiha LI Bo DENG Yu-Lin 欧阳飞凡;RASHEED Madiha;李博;邓玉林

作者机构：Advanced Research Institute of Multidisciplinary ScienceBeijing Institute of TechnologyZhuhai 519088China Beijing Key Laboratory for Separation and Analysis in Biomedicine and PharmaceuticalsSchool of Life ScienceBeijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary ScienceBeijing Institute of TechnologyBeijing 100081China 

基　　金：国家自然科学基金(82202072) 北京理工大学科技创新计划科研基地科技专项计划资助项目 

出 版 物：《生物化学与生物物理进展》 (Progress In Biochemistry and Biophysics)

年 卷 期：2024年第51卷第9期

页      码：2082-2100页

摘      要：Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,defined by several phases,ranging from benign fat accumulation to non-alcoholic steatohepatitis(NASH),which can lead to liver cancer and *** NAFLD is a disease of disordered metabolism,it also involves several immune cell-mediated inflammatory processes,either promoting and/or suppressing hepatocyte inflammation through the secretion of pro-inflammatory and/or anti-inflammatory factors to influence the NAFLD ***,the underlying disease mechanism and the role of immune cells in NAFLD are still under investigation,leaving many open-ended *** this review,we presented the recent concepts about the interplay of immune cells in the onset and pathogenesis of *** also highlighted the specific non-immune cells exhibiting immunological properties of therapeutic significance in *** hope that this review will help guide the development of future NAFLD therapeutics.

主 题 词：non-alcoholic fatty liver disease metabolically associated fatty liver disease(MAFLD) T cells myeloid cells mesenchymal stem cells 

学科分类：1002[医学-临床医学类] 1001[医学-基础医学] 100201[100201] 100102[100102] 100104[100104] 10[医学] 

核心收录：

D　O　I：10.16476/j.pibb.2024.0045

馆 藏 号：203140926...