High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

作     者：Si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Si Chen;Fang Huang;Lijie Mao;Zhimin Zhang;Han Lin;Qixin Yan;Xiangyu Lu;Jianlin Shi

作者机构：Department of CardiologyShanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic MedicineSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China 

基　　金：supported by the National Key Research and Development Program of China(Grant No.2022YFB3804500) the National Natural Science Foundation of China(Grant No.52202352,22335006) the Shanghai Municipal Health Commission(Grant No.20224Y0010) the CAMS Innovation Fund for Medical Sciences(Grant No.2021-I2M-5-012) the Basic Research Program of Shanghai Municipal Government(Grant No.21JC1406000) the Fundamental Research Funds for the Central Universities(Grant No.22120230237,2023-3-YB-11,22120220618) the Basic Research Program of Shanghai Municipal Government(23DX1900200) 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2025年第17卷第2期

页      码：187-203页

摘      要：The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

主 题 词：Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis 

学科分类：1007[医学-药学类] 081705[081705] 08[工学] 0817[工学-轻工类] 100701[100701] 10[医学] 

核心收录：

D　O　I：10.1007/s40820-024-01522-1

馆 藏 号：203144076...