Composite bioabsorbable vascular stents via 3D bio-printing and electrospinning for treating stenotic vessels

作     者：刘媛媛 向科 李瑜 陈海萍 胡庆夕 Liu Yuanyuan;Xiang Ke;Li Yu;Chen Haiping;Hu Qingxi

作者机构：上海大学快速制造工程中心上海200444 上海大学上海市智能制造及机器人重点实验室上海200072 

基　　金：The National Natural Science Foundation of China(No.51475281,51375292) the National Natural Science Foundation for Young Scholar of China(No.51105239) 

出 版 物：《Journal of Southeast University(English Edition)》 (东南大学学报（英文版）)

年 卷 期：2015年第31卷第2期

页      码：254-258页

摘      要：A new type of vascular stent is designed for treating stenotic vessels. Aiming at overcoming the shortcomings of existing equipment and technology for preparing a bioabsorbable vascular stent （BVS）, a new method which combines 3D bio-printing and electrospinning to prepare the composite bioabsorbable vascular stent （CBVS） is proposed. The inner layer of the CBVS can be obtained through 3D bio- printing using poly-p-dioxanone （PPDO）. The thin nanofiber film that serves as the outer layer can be built through electrospinning using mixtures of chitosan-PVA （poly （vinyl alcohol））. Tests of mechanical properties show that the stent prepared through 3D bio-printing combined with electrospinning is better than that prepared through 3D bio- printing alone. Cells cultivated on the CBVS adhere and proliferate better due to the natural, biological chitosan in the outer layer. The proposed complex process and method can provide a good basis for preparing a controllable drug-carrying vascular stent. Overall, the CBVS can be a good candidate for treating stenotic vessels.

主 题 词：3D ( three-dimensional ) bio-printing bioabsorbable vascular stent (BVS) electrospinning cellproliferation composite forming 

学科分类：12[管理学] 1201[管理学-管理科学与工程类] 08[工学] 0802[工学-机械学] 080201[080201] 

核心收录：

D　O　I：10.3969/j.issn.1003-7985.2015.02.017

馆 藏 号：203146274...